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You cannot open exe files when your computer infected with w32/sircam or any similar type of virus.when try to open any exe files or any programs , you may get thefollwing type of messages

The system cannot find the file
or Windows cannot file this file select program from a list

the reason is ,virus can change the default configuration for running EXE files. This may lead to failed operation when you try to run EXE files. the following solution will help you to fix the problem after removal of viruses

1- Go to start and click run
2- type command.com and press OK.this will open command prompt.
3- type cd\ and press enter to get root of C drive
4- type cd \windows press enter
5- Type copy regedit.exe regedit.com and then press Enter
6- Navigate to and select the key:
HKEY_CLASSES_ROOT\exefile\shell\open\command
7- In the right pane, double-click the (Default) value.
8- Delete the current value data, and then type:
"%1" %*
Tip: Type the characters: quote-percent-one-quote-space-percent-asterisk.
9- Close Regedit utility and restart your computer.

Now the problem should be solved